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KMID : 0648320140200010021
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Journal of The Korean Society of Hypertension
2014 Volume.20 No. 1 p.21 ~ p.30
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Effects of Valsartan on Carotid Arterial Stiffness in Patients with Newly Diagnosed Hypertension: A Comparative Study with Global Arterial Stiffness
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Yim Yi-Rang
Kim Kye-Hun
Cho Jae-Young
Yoon Hyun-Ju
Hong Young-Joon
Park Hyung-Wook
Kim Ju-Han
Ahn Young-Keun
Jeong Myoung-Ho
Cho Jeong-Gwan
Park Jong-Chun
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Abstract
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Background: To compare the parameters of local carotid stiffness with those of global arterial stiffness and to investigate the effects of angiotensin II receptor blocker (ARB) on the parameters of local carotid arterial stiffness as well as global arterial stiffness.
Methods: The correlations of the parameters between local carotid and global arterial stiffness were compared at baseline, and the changes of these parameters were evaluated after 6 months of valsartan therapy in 50 patients with newly diagnosed hypertension. Diameter change, strain, and 2-dimensional circumferential strain (2D CS) of the carotid artery measured by speckle tracking method were used as parameters of local arterial stiffness, and the parameters of pulse wave velocity (PWV) and pulse wave analysis (PWA) were used as standard parameters of global arterial stiffness.
Results: Carotid 2D CS, not conventional strain or diameter change, showed significant correlation with age (r = -0.592, p < 0.01), brachial-ankle PWV (r = -0.338, p < 0.05), and augmentation index (r = -0.298, p < 0.05). After 6 months of medical therapy, systolic blood pressure (SBP) and diastolic blood pressure (DBP) were decreased significantly (SBP: 155.9 ± 14.2 to 137.6 ± 10.5 mm Hg, p < 0.01; DBP: 90.1 ± 11.8 to 81.6 ± 8.0 mm Hg, p < 0.01). The parameters of PWV and PWA were significantly improved, but the parameters of carotid arterial stiffness were not changed significantly.
Conclusions: In hypertensives, carotid 2D CS showed better correlation with ageing and the parameters of global arterial stiffness than conventional strain or diameter change of the carotid artery. Global arterial stiffness was improved by 6 months of medical treatment with ARB, but the local carotid arterial stiffness was not changed.
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KEYWORD
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Vascular stiffness, Hypertension, Angiotensin receptor antagonists
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